A Lesson of Three Bs
نویسندگان
چکیده
Angiogenesis and its regulation is a crucial physiological response to chronic tissue ischemia causing increased microvessel growth along with collateral arteriolar remodeling to restore blood flow to deprived tissues.1 Vascular occlusion, as seen in coronary and peripheral artery disease, often progresses to chronic tissue ischemia without effective vascular remodeling responses.2 Thus, therapeutic revascularization has an important role to play in the management of patients with coronary or peripheral artery disease to facilitate ischemic tissue reperfusion and limit cellular injury and loss.3 Unfortunately, successful realization of therapeutic angiogenesis remains elusive despite numerous experimental and clinical studies.
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