Hyperoxia-induced neonatal rat lung injury involves activation of TGF- and Wnt signaling and is protected by rosiglitazone
نویسندگان
چکیده
Chiranjib Dasgupta, Reiko Sakurai, Ying Wang, Pinzheng Guo, Namasivayam Ambalavanan, John S. Torday, and Virender K. Rehan Departments of Pediatrics and Obstetrics and Gynecology, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, David Geffen School of Medicine at UCLA, Torrance, California; and Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama
منابع مشابه
Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone.
Despite tremendous technological and therapeutic advances, bronchopulmonary dysplasia (BPD) remains a leading cause of respiratory morbidity in very low birth weight infants, and there are no effective preventive and/or therapeutic options. We have previously reported that hyperoxia-induced neonatal rat lung injury might be prevented by rosiglitazone (RGZ). Here, we characterize 1) perturbation...
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The physiological development and homeostasis of the lung alveolus is determined by the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) by the interstitial lipofibroblast. We have recently shown (Dasgupta C et al., Am J Physiol Lung Cell Mol Physiol 296: L1031-L1041, 2009.) that PPAR-γ agonists administered postnatally accelerate lung maturation and prevent hyperoxia-induced...
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