Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable parameter to improve drug delivery
نویسندگان
چکیده
vascular tone as a tunable parameter to improve drug delivery. Philippe Martinive, Julie DeWever, Caroline Bouzin, *Christine Baudelet, Pierre Sonveaux, Vincent Grégoire, *Bernard Gallez and Olivier Feron. Unit of Pharmacology and Therapeutics (FATH 5349), *Laboratory of Biomedical Magnetic Resonance; Center for Molecular Imaging and Experimental Radiotherapy, University of Louvain (UCL) Medical School, B-1200 Brussels, Belgium. ([email protected])
منابع مشابه
Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery.
Maturation of tumor vasculature involves the recruitment of pericytes that protect the endothelial tubes from a variety of stresses, including antiangiogenic drugs. Mural cells also provide mature tumor blood vessels with the ability to either relax or contract in response to substances present in the tumor microenvironment. The observed cyclic alterations in tumor blood flow and the associated...
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