Dubin-Johnson syndrome in a Saudi neonate.
نویسندگان
چکیده
There are many disorders associated with direct hyperbilirubinemia in the neonatal period. These usually need urgent referral to identify treatable diseases. DubinJohnson Syndrome (DJS), which results from impaired hepatic excretory function, is an uncommon cause of neonatal jaundice and is only sporadically reported in neonates. We report here a neonate who presented with direct hyperbilirubinemia in the newborn period. To the best of our knowledge, DJS has not been reported previously in neonates from Saudi Arabia.
منابع مشابه
معرفی یک مورد بیمار مبتلا به سندرم دوبین جانسون
Hyperbilirubinemia is a common manifestation in internal medicine. It is divided to conjugated and unconjugated hyperbilirubinemia . Conjugated hyperbilirubinemia usually results from hepatocellular or cholestatic liver disease or from extrahepatic biliary obstruction. Isolated conjugated hyperbilirubinemia is the primary manifestation of two heritable disorders, Rotor and Dublin – Johnso...
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Les auteurs presentent quatre cas familiaux de l'ictcre chronique, non hemolytique, benin, avec une hyperbilirubinemie a predominance conjuguee. Deux malades ont ete soumis a des investigations plus poussees. Les. voies biliaires etaient visib1es a la cholecystographie ora1e et le taux plasmatique de la BSP, elevc au depart, presentait une pente d'elimination progressive sans remontee secondai...
متن کاملDubin-Johnson syndrome presenting with neonatal cholestasis.
We report a case of Dubin-Johnson syndrome presenting with neonatal cholestasis. Liver histology was studied during the neonatal period and at 6 years of age. Distinct brownish pigment granules in hepatocytes were noted. This case confirms that Dubin-Johnson syndrome is a cause of neonatal cholestasis.
متن کاملA case of the Dubin-Johnson syndrome complicated by acute hepatitis.
A patient is described in whom the Dubin-Johnson syndrome was diagnosed after an attack of acute hepatitis at the age of 21. In the eight years following the hepatitis Dubin-Johnson pigment, initially scanty, developed to classical proportions. The defect in intracellular transport of bilirubin was thought to precede the attack of acute hepatitis.
متن کاملAbnormal Excretion O F T H E Isomers of U R I N a R Y Coproporphyrin by Patients with Dubin - Johnson S
1. The urinary excretion of isomers I and I11 of coproporphyrin by fifty-nine patients with Dubin-Johnson syndrome has been examined, and compared with the results obtained for normal control subjects and patients with various types ofjaundice. 2. The control subjects (with one exception) excreted less than 45% of the coproporphyrin as isomer I. Fifty-six patients with the Dubin-Johnson syndrom...
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ورودعنوان ژورنال:
- Annals of Saudi medicine
دوره 16 6 شماره
صفحات -
تاریخ انتشار 1996