Mining residue contacts in proteins using local structure predictions
نویسندگان
چکیده
In this paper we develop data mining techniques to predict 3D contact potentials among protein residues (or amino acids) based on the hierarchical nucleation-propagation model of protein folding. We apply a hybrid approach, using a hidden Markov model to extract folding initiation sites, and then apply association mining to discover contact potentials. The new hybrid approach achieves accuracy results better than those reported previously.
منابع مشابه
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عنوان ژورنال:
- IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society
دوره 33 5 شماره
صفحات -
تاریخ انتشار 2003