Synthesis of (+)-madindoline A and (+)-madindoline B.
نویسندگان
چکیده
The allene ether version of the Nazarov cyclization was used to construct the cyclopentane dione portion of madindolines A and B. The racemic cyclopentane dione from the Nazarov cyclization was converted to an enol ether that was combined with the chiral, nonracemic hydroxyfuroindoline in a Mannich reaction. Deprotection and oxidation led to (+)-madindoline A and (+)-madindoline B. [reaction: see text].
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ورودعنوان ژورنال:
- Organic letters
دوره 9 4 شماره
صفحات -
تاریخ انتشار 2007