Molecular Characterization of Streptococcus pyogenes Isolated from Children with Pharyngitis

Submit Manuscript | http://medcraveonline.com [1]. Streptococcal pharyngitis is most significant disease, and its peak incidence occurs in children, these infections impose the economic burden on the society [2]. The symptoms of streptococcal pharyngitis include a sore throat, pain in swallowing, fever, swollen, and tender lymph nodes in the neck and fatigue [3]. S. pharyngitis oftenly results from direct contact with another person with streptococcal pharyngitis [4]. Asymptomatic carriers can play a role in transmission, particularly during outbreaks. S. pyogen contact large number of virulence factor that’s contributing to its pathogenicity, important virulence factor [5], encoded by emm gene are superantigen protein, and M protein is an important virulence factor of s. pyogenes [6]. superantigens are a potent immune stimulatory activity that contributes to the pathogenesis of Streptococcus pyogens. The gene distribution of sAgs has used as an epidemiologic tool to explore genomic heterogeneity and the possible correlation between super antigen gene content and clinical manifestation [7].