Quantification of Microtubule Stabilizing Drug Treatment effect on Axonal Transport Rate in a Transgenic Mouse Model of Alzheimers Disease
نویسندگان
چکیده
J. Kim, I-Y. Choi, M. L. Michaelis, and S-P. Lee Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Neurology, University of Kansas Medical Center, Kansas City, KS, United States, Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
منابع مشابه
Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy
Neurodegenerative disorders referred to as tauopathies, which includes Alzheimer's disease (AD), are characterized by insoluble deposits of the tau protein within neuron cell bodies and dendritic processes in the brain. Tau is normally associated with microtubules (MTs) in axons, where it provides MT stabilization and may modulate axonal transport. However, tau becomes hyperphosphorylated and d...
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