Binding biomolecules with designed, hydrogen- bonding receptors
نویسندگان
چکیده
An approach to the design of artificial receptors is described involving the fusion of several sixmembered rings, preorganizing nitrogen and oxygen hydrogen bonding sites. A hexagonal lattice chemosensor extracts the blood metabolite creatinine into water and acts as a chromogenic reagent for this clinical analyte. Another receptor binds urea via six hydrogen bonds, forming a complex that is stable even in DMSO. A water-soluble receptor has now been synthesized that recognizes the guanidinium sidechain of arginine in aqueous media.
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