Title : Enhanced targeting of the EGFR network with MM - 151 , an oligoclonal anti - EGFR antibody therapeutic
نویسندگان
چکیده
Title: Enhanced targeting of the EGFR network with MM-151, an oligoclonal anti-EGFR antibody therapeutic Authors: Jeffrey D. Kearns, Raghida Bukhalid, Mark Sevecka, Gege Tan, Nastaran Gerami-Moayed, Shannon L. Werner, Neeraj Kohli, Olga Burenkova, Callum M. Sloss, Anne M. King, Jonathan B. Fitzgerald, Ulrik B. Nielsen, Beni B. Wolf Authors’ Affiliation: Merrimack Pharmaceuticals, Cambridge, Massachusetts Corresponding Author: Jeffrey D. Kearns, Merrimack Pharmaceuticals, One Kendall Square, Suite B7201, Cambridge, MA 02139. Phone: 617-441-1000; Fax: 617-491-1386; E-mail: [email protected] Running Title: Enhanced inhibition of EGFR signal amplification by MM-151
منابع مشابه
Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic.
Although EGFR is a validated therapeutic target across multiple cancer indications, the often modest clinical responses to current anti-EGFR agents suggest the need for improved therapeutics. Here, we demonstrate that signal amplification driven by high-affinity EGFR ligands limits the capacity of monoclonal anti-EGFR antibodies to block pathway signaling and cell proliferation and that these l...
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