Modulation of TNF-a–Induced Apoptosis in Corneal Fibroblasts by Transcription Factor NF-kB
نویسندگان
چکیده
PURPOSE. Previous studies have suggested no role for tumor necrosis factor (TNF)-a in the modulation of apoptosis in corneal fibroblasts. However, recent investigations have demonstrated that nuclear factor (NF)-kB activation by TNF-a mediates negative apoptotic effects that must be blocked to unmask the apoptotic effects of TNF-a in vitro. The purpose of this study was to investigate the role of transcription factor NF-kB in the suppression of TNF-a–induced apoptosis of corneal fibroblasts.
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