Genomics for natural product discovery
نویسنده
چکیده
The Natural Product Discovery Institute contains a set of more than 30 000 fungal and actinomycete organisms that can be used for natural product discovery. The natural product library contains purified compounds, partially purified column fractions, and crude extracts from natural product-producing organisms. The collection is available for screening. This site describes a roadmap for analysing the gen-omes of Actinobacteria for natural product biosynthetic pathways. Phosphonic acid natural products via genome mining In this study, data from the large-scale sequencing of actinomycetes were mined to uncover new metabolic pathways for making phosphonic acid natural products. Biosynthetic phosphonic acids are often metabolite mimics that have interesting biological properties.
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