Electromyographic characterization in an animal model of dystonia.
نویسندگان
چکیده
Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been similarly utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulfadimethoxine to exacerbate bilirubin toxicity and compared to saline treated jjs and non-jaundiced (Nj) littermates. Electromyographic (EMG) activity was recorded from antagonistic hip muscles in dystonic and in normal appearing rats. Raw EMG signals were decomposed using the Discrete Wavelet Transform based multi-resolution analysis and signal coefficients corresponding to the dominant EMG frequency band were chosen. Gunn rats exposed to sulfadimethoxine developed a stable clinical state characterized by prolonged abnormal axial and appendicular postures. Coherence plots of the separated signals coefficients revealed 4-7 Hz co-activation in antagonistic muscles that was significantly more prominent in jj sulfa treated dystonic compared to normal rats. The EMG findings support the presence of dystonia in sulfadimethoxine exposed jj Gunn rats and suggest that these animals can serve as a valuable model for experimental investigations of dystonia.
منابع مشابه
Multichannel Electromyographic Mapping to Optimize OnabotulinumtoxinA Efficacy in Cervical Dystonia
BACKGROUND Cervical dystonia (CD) is characterized by sustained, involuntary contraction of head and neck muscles. Botulinum toxin injections are established as safe and effective, but unfortunately 15-25% of patients fail to respond. The aim of this study was to examine whether multichannel electromyogaphic mapping improved outcomes in a cohort of antibody-negative onabotulinumtoxinA non-respo...
متن کاملCHARACTERIZATION OF IMMUNE RESPONSE TO MUSTARD GAS USING A NEW FLUOROIMMUNOASSAY
One way to confront chemical warfare in order to reduce their harmful effects, is to use the body's defense mechanisms. In order to do so firstly mustard gas (HD) was injected in an animal model in the form of an immunogen and the induced humoral immune response was investigated by two different immunological methods such as the Ouchterlony test and a new liquid phase fluoroimmunoassay. 7l...
متن کاملThe brighter side of music in dystonia.
OBJECTIVE To report a patient with genetically proven DYT1 dystonia who shows dramatic improvement in symptoms while playing the piano. DESIGN Case study. SETTING Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, England. PATIENT A 49-year-old right-handed male civil servant. MAIN OUTCOME MEASURES The patient was videotap...
متن کاملTreatment of adductor spasmodic dysphonia with selective laryngeal adductor denervation and reinnervation surgery.
Spasmodic dysphonia (SD) is a voice disorder characterized by abnormal intermittent spasms of intralaryngeal muscles that result in voice breaks during speech. In the adductor variant of spasmodic dysphonia (ADSD), spasms of the adductor muscles cause strangled voice breaks and a strained-strangled voice quality. In the abductor variant (ABSD), spasms of the posterior cricoarytenoid muscle (PCA...
متن کاملPallidaldeep brain stimulation for the treatment of DYT6 dystonia: a case report and review of literature
Little is known about the results of pallidal deep brain stimulation (DBS) in DYT6 dystonia. This will be the first report of DYT6 dystonia treated with pallidal DBS from Iran. A 21 years old male patient with DYT6 dystonia underwent bilateral deep brain stimulation. The target of DBS was the sensorimotor region of the posteroventralglobuspallidusinternus (GPi). DBS parameters included an amp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Movement disorders : official journal of the Movement Disorder Society
دوره 23 8 شماره
صفحات -
تاریخ انتشار 2008