Neurotransmitter : Release

The nervous system is composed of networks of cells that engage in coordinated circuits to permit neural function. Within these precise neural circuits, communication between individual cells is primarily chemical in nature. Neurotransmitter release via exocytosis of neurotransmitter-filled synaptic vesicles is a fundamental step in this process. Here we overview the biochemical processes that regulate exocytotic neurotransmitter release by focusing on three key stages: 1) loading of neurotransmitter into synaptic vesicles, 2) synaptic vesicle docking and priming reactions, and 3) calcium triggering of the vesicle fusion reaction. We also introduce the controversial topic of fusion-pore modulation as it pertains to the release of neurotransmitter. Lastly, we discuss current methods for detecting and quantifying neurotransmitter release.