Increased Release of Plasminogen Activator Inhibitor Type 2 Accompanies the Human Mononuclear Cell Tissue
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چکیده
Human peripheral blood mononuclear cells (PBM) respond to Iipopolysaccharide (LPS) with increased release of a plasminogen activator (PA) inhibitor. This response is dose dependent and parallels the IPS-induced expression of PBM tissue factor activity. The PA inhibitors of control and IPS-stimulated PBMs appear identical as both are identifled by antibodies to PA inhibitor type 2 of human placenta, but not by antibodies to type 1 inhibitor of bovine aortic endothelial cells. The PA inhibitor is specific for urokinase type PA as determined by the 125l-fubrin plate assay, and direct cleavage of 125l-plasminogen; it does not effectively inhibit tissue-type PA. The inhibitor forms an active site-
منابع مشابه
Increased release of plasminogen activator inhibitor type 2 accompanies the human mononuclear cell tissue factor response to lipopolysaccharide.
Human peripheral blood mononuclear cells (PBM) respond to lipopolysaccharide (LPS) with increased release of a plasminogen activator (PA) inhibitor. This response is dose dependent and parallels the LPS-induced expression of PBM tissue factor activity. The PA inhibitors of control and LPS-stimulated PBMs appear identical as both are identified by antibodies to PA inhibitor type 2 of human place...
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