PEComa with Transcription Factor E3 Overexpression: A Diagnostic and Therapeutic Challenge
نویسندگان
چکیده
PEComa with transcription factor E3 overexpression, most commonly through gene rearrangement, represents a biologically distinct subset of disease. We present here an illustrative case to highlight its diagnostic and therapeutic challenge in the context of potential pathogenic signaling pathways.
منابع مشابه
Perivascular epithelioid cell tumor (PEComa) of the urinary bladder associated with Xp11 translocation.
Perivascular epithelioid cell-containing tumors (PEComas) represent a rare family of neoplasms. Their dichotomous phenotypic features, including both myogenic and mylanocytic features, can make a definitive diagnosis difficult. Such tumors have been associated with the overexpression of transcription factor E3 (TFE3). An Xp11 translocation could account for the aberrant activity of TFE3 but has...
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