Clinical Study Gamma-Irradiated Bacille Calmette-Guérin Vaccination Does Not Modulate the Innate Immune Response during Experimental Human Endotoxemia in Adult Males
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Gamma-Irradiated Bacille Calmette-Guérin Vaccination Does Not Modulate the Innate Immune Response during Experimental Human Endotoxemia in Adult Males
Bacille Calmette-Guérin (BCG) vaccine exerts nonspecific immunostimulatory effects and may therefore represent a novel therapeutic option to treat sepsis-induced immunoparalysis. We investigated whether BCG vaccination modulates the systemic innate immune response in humans in vivo during experimental endotoxemia. We used inactivated gamma-irradiated BCG vaccine because of the potential risk of...
متن کاملGamma-irradiated bacille calmette-guÉrin vaccination does not modulate the innate immune response during experimental human endotoxemia
Introduction Recent insights in sepsis pathology have led to the view that not the initial hyperinflammatory state, but rather a profoundly suppressed state of the immune system, also called immunoparalysis, accounts for the majority of sepsis-related deaths. Therefore, reconstitution of immunocompetence in sepsis is emerging as a promising therapeutic target to improve outcome. Bacille Calmett...
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Background: The BCG vaccine, used since 1921 to prevent tuberculosis (TB), considered the world's most widely used vaccine. This study aimed to investigate the frequency and the type of complications associated with Bacillus Calmette-Guérin (BCG) vaccination in Iranian children. Materials and Methods This cross-sectional study conducted for 6months among children aged up to 18 months who presen...
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