Proline, glutamic acid, and leucine rich protein 1 (PELP1) expression in deep paravertebral muscles in idiopathic scoliosis girls
نویسندگان
چکیده
Objectives Estrogens and their receptors are postulated to be important factors in development of idiopathic scoliosis. Transcription functions of estrogen receptors are influenced by coregulators such as proline, glutamic acid, and leucine rich protein 1 (PELP1). Deep paravertebral muscles are potential elements participating in idiopathic scoliosis development. The aim of the present study was to evaluate PELP1 mRNA expression levels and the protein presence in deep paravertebral muscles on both sides of the spinal curve and correlation between the expression level and scoliosis parameters.
منابع مشابه
Expression of Estrogen Receptor Coactivator Proline-, Glutamic Acid- and Leucine-Rich Protein 1 within Paraspinal Muscles in Adolescents with Idiopathic Scoliosis
PURPOSE The aim of this study was to detect and assess the estrogen receptor (ESR) coactivator PELP1 expression within human paraspinal skeletal muscles in patients suffering from idiopathic scoliosis. METHODS During surgical correction of scoliosis the muscle biopsies harvested in 29 females. Presence of PELP1, ESR1 and ESR2 genes transcripts was studied using RT-qPCR technique while immunoh...
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