Biomedical applications of boronic acid polymers
نویسندگان
چکیده
Boron-containing organic compounds have found widespread use in synthetic organic chemistry. More recently, boronic acid-containing polymers have proven valuable in a variety of biomedical applications, including the treatment of HIV, obesity, diabetes, and cancer. However, as compared to many other classes of functional polymers, boronic acid-containing (co)polymers remain underutilized, despite their unique reactivity, solubility, and responsive nature. This Feature Article highlights research in this area, with particular focus on recent developments in synthesis, processing, and materials development that have enabled the preparation of new biomaterials. In addition to providing an overview to the current state of the art, we emphasize the versatility of boronic acid polymers and suggest routes for their further employment in other potential biomedical applications. 2011 Elsevier Ltd. All rights reserved.
منابع مشابه
Responsive Boronic Acid-Decorated (Co)polymers: From Glucose Sensors to Autonomous Drug Delivery
Boronic acid-containing (co)polymers have fascinated researchers for decades, garnering attention for their unique responsiveness toward 1,2- and 1,3-diols, including saccharides and nucleotides. The applications of materials that exert this property are manifold including sensing, but also self-regulated drug delivery systems through responsive membranes or micelles. In this review, some of th...
متن کاملFluorescent Boronic Acid Polymer Grafted on Silica Particles for Affinity Separation of Saccharides
Boronic acid affinity gels are important for effective separation of biological active cis-diols, and are finding applications both in biotech industry and in biomedical research areas. To increase the efficacy of boronate affinity separation, it is interesting to introduce repeating boronic acid units in flexible polymer chains attached on solid materials. In this work, we synthesize polymer b...
متن کاملPhenylboronic Acid-Functionalized Layer-by-Layer Assemblies for Biomedical Applications
Recent progress in the development of phenylboronic acid (PBA)-functionalized layer-by-layer (LbL) assemblies and their biomedical applications was reviewed. Stimuli-sensitive LbL films and microcapsules that exhibit permeability changes or decompose in response to sugars and hydrogen peroxide (H2O2) have been developed using PBA-bearing polymers. The responses of PBA-modified LbL assemblies ar...
متن کاملBoronic acid ester with dopamine as a tool for bioconjugation and for visualization of cell apoptosis.
Boronic esters are investigated as a pathway to conjugate biological molecules to polymers. Although the stability of the boronic ester was slightly dependent on the molecular weight of the polymer and the pH value, the conjugates were stable when micelles were endocytosed by cells. Only the onset of apoptosis led to cleavage of the boronic ester.
متن کاملRatiometric Sensing of Hydrogen Peroxide Utilizing Conformational Change in Fluorescent Boronic Acid Polymers
We demonstrate that the copolymers containing boronic acid and pyrene units can be utilized for the fluorometric sensing of hydrogen peroxide (H2O2) in aqueous solutions. The copolymer exists in a relatively extended conformation in the absence of H2O2, whereas the polymer chain is contracted by the reaction of boronic acid moieties with H2O2 to form phenol groups. This conformational change in...
متن کامل