Acquired cupping of the optic nerve head in normotensive eyes.
نویسندگان
چکیده
Clinical measurements of a horizontal cup/disc ratio were obtained among a sample of 160 normal twin subjects by stereoscopic biomicroscopy. Measurements of horizontal cup/disc ratio were normally distributed and theere was no significant association with sex, laterally, race, or refractive error in the mid-range. However, there was a significant association between size of the cup/disc ratio and age as well as intraocular pressure. After taking into account the correlation between age an intraocular pressure in normal eyes, the association between cup/disc ratio and each of these variable remained statistically significant. It is not always recoginized that the size of the normal physiological cup increases with age, and it was not previously observed that "normal" cupping occurs with age apart from the effect of pressure. The average effect of age on cup/disc ratio, amounting to an icrease of 0-0026 per year for this sample, is small. But, allowing for individual variation, some persons could show a recognizable acquired increase in cup/disc ration with age, even in the absence of glaucoma. The possibility of "normal"cupping occurring in association with age, pressure, or high myopia, alone or in combination, merits cosideration in the clinical evaluation of glaucoma suspects and serves to re-emphasize the importance of an adequate central visual field examination in the diagnosis of glaucoma. Studies are needed on the differentiatin between "normal" and "morbid" moulding of the optic nerve head.
منابع مشابه
Distribution and expression of transforming growth factor-beta and platelet-derived growth factor in the normal and glaucomatous monkey optic nerve heads.
PURPOSE Remodeling of the extracellular matrix occurs in the lamina cribrosa in progressed glaucomatous optic nerve damage including disc cupping. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally induced glaucoma model. METHODS We used 3 cynomolgus and 2 Japanese monkey e...
متن کاملOptic nerve head drusen and visual field loss in normotensive and hypertensive eyes.
OBJECTIVE To compare visual field loss (VFL) in eyes with optic nerve head drusen (ONHD) with or without ocular hypertension (OHT). METHODS The records of all patients aged 45 years or older with a diagnosis of ONHD at 2 centers were reviewed. OHT was defined as intraocular pressure >or=22 mm Hg. We categorized ONHD into 3 grades based on visibility on disc photographs. RESULTS We identifie...
متن کاملLetter to the Editor: A Case of Optic Nerve Atrophy with Severe Disc Cupping after Methanol Poisoning
We report a rare case of optic nerve atrophy with severe disc cupping resulting from methanol poisoning. A 30-year-old man presented to the hospital complaining of decreased visual acuity in both eyes a day after drinking alcohol containing methanol. His initial visual acuity allowed for only visualizing hand motion and not corrected in either eye. Initial intraocular pressure was within normal...
متن کاملEffects of short term increase of intraocular pressure on optic disc cupping.
AIMS To evaluate the effect of acute elevation of intraocular pressure (IOP) on optic disc cupping. METHODS 10 emmetropic and 10 myopic volunteers were included in this study. The cup area (CA) and cup volume (CV) of the optic disc were determined with the Heidelberg retina tomograph (HRT). After baseline determinations, a suction cup was used to increase the intraocular pressure (IOP) to 20-...
متن کاملDifferentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography
BACKGROUND In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiating glaucomatous from non-glaucomatous optic nerve cupping in a cross-sectional pilot study. METHODS Eleven consecutive patients presenting to...
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 59 4 شماره
صفحات -
تاریخ انتشار 1975