Research Summary and Plan
نویسنده
چکیده
My research on algorithms applies to two general areas, mathematical biology and number theory. My switch to biological problems is recent. The broader impact of extracting information from biological sequences is great, despite the difficulty of precise problem definition. My graduate thesis develops a specialized number theory algorithm which converts a question about modular forms into a combinatorial problem. The basic problem of finding the prime divisors of an integer is a continuing interest of mine. I continue to consult for Institute for Defense Analyses (IDA), due to the application of number theory to cryptography. I plan to continue developing biological sequence comparison algorithms. Goals include gaining insight into the process of evolution and understanding the semantics of the genetic code. In the immediate future, I will refine the methods I describe below. Probabilitistic pairwise visualization (PPV) allows sequences to be compared using a data array which translates into an image showing regions of higher and lower correlation. The numerical data can then be processed by digital image techniques. It is a challenging programming problem to generalize to multiple sequences. Traceback and realignment of gaps (TAR) is a separate algorithm designed as part of an improvement to the CLUSTAL progressive multiple sequence alignment. These methods have been tested on data from mouse, rat, and yeast. They can each benefit from development of stronger underlying models of evolution. I would like to use them to go beyond the information developed using other strategies, examining both larger and more complex data sets.
منابع مشابه
Preparing effective grant applications.
The abstract and specific aims (described below) sections, two of the most important components of any grant application, must provide a cohesive framework for the application. The abstract provides an outline of the proposed research for the funding agency and the reviewers. Despite the fact that the abstract comes before the research plan in the physical document and is probably read before t...
متن کاملResearch Summary: Datalog-Based Data Access
This paper presents the research summary of a Ph.D. plan concerning the study of Ontology-Based Data Access (OBDA) for ontologies expressed in Datalog-based formalisms, i.e., Datalog rules that allow the use of existential variables in the head.
متن کاملResearch Summary
My main area of research is theoretical computer science, computational complexity and computational logic, with an emphasis on proof complexity and its connection to algebraic complexity. The Summary section below contains a short description of my previous work, my intended research plans and my longterm research goals. The sections after it contain background and a more detailed description ...
متن کاملVisual Indoor Localization with a Floor-Plan Map
In this report, a indoor localization method is presented. The method takes firstperson view video clip as input and uses a 2D floor-plan map as prior knowledge. Motivation, methodology, elementary experimental results, and further extensions are reported and discussed. This report also serves as a brief research summary for CS 6756.
متن کامل