Geranylgeranylation of Rab proteins.
نویسندگان
چکیده
37 James, G. L., Goldstein, J. I,., Brown, M. S., Rawson, T. E., Somers, T. C., McDowell, R. S., Crowlcy, C. W., Lucas, B. K., Levinson, A. D. and Marsters, Jr., J. C. (1993) Science 260, 1937-1942 38 Cox, A. D., Garcia, A. M., Westwick, J. K., Kowalczyk, J. J., Lewis, M. D., Brenner, D. A. and Iler, C. J. (1994) J. Biol. Chem. 269, 19203-19206 39 Manne, V., Yan, N., Carlioni, J. M., Tuomari, A. V., Ricca, C. S., Brown, J. G., Andahzay, M. L., Schmidt, R. J., Patel, D., Zahler, R. et al. (1995) Oncogene 10, 1763-1779 40 I,erner, E. C., Qian, Y., Hamilton, A. D. and Sebti, S. M. (1995) J. Biol. Chem. 270, 26770-26773 41 Stanton, Jr., V. P., Nichols, D. W., I,audano, A. P. and Cooper, G. M. (1989) Mol. Cell. Riol. 9,
منابع مشابه
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to membranes. The REP-like protein Rab GDP dissociation inhibit...
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Rab GTPases participating in the regulation of vesicle trafficking in eukaryotes are geranylgeranylated by the Rab geranylgeranyl transferase (RabGGTase) in complex with the Rab escort protein (REP). Here, we describe basic properties of the Arabidopsis thaliana REP (AthREP), first REP outside yeasts or metazoans to be characterized. GFP-tagged AthREP, as well as the geranylgeranylation activit...
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Modification of proteins at C-terminal cysteine residues by the isoprenoids farnesyl (C15) or geranylgeranyl (C20) is essential for the membrane association and biological function of several eukaryotic proteins (for reviews, see 1, 2). Farnesylation is signalled by a C-terminal -CAAX motif where C is cysteine, A is aliphatic and X is usually serine or methionine. Farnesyltransferase (FTase) ut...
متن کاملRab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and reduced platelet alpha- and delta-granule contents. Here we show by positional cloning that gm results from a G-->A substitution mutation in a splice acceptor site within the alpha-subunit of Rab geranylg...
متن کاملInsulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4.
Rab proteins play a crucial role in the trafficking of intracellular vesicles. Rab proteins are GTPases that cycle between an inactive GDP-bound form and an active GTP-bound conformation. A prerequisite to Rab activation by GTP loading is its post-translational modification by the addition of geranylgeranyl moieties to highly conserved C-terminal cysteine residues. We examined the effect of ins...
متن کاملGeranylgeranylation of Rab GTPases
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT. After geranylgeranylation of Rab C-terminal cysteines, REP delivers the prenylated protein to membranes. The REP-like protein Rab GDP dissociation inhibit...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1996