Extracellular volume fraction measured by MOLLI: slow infusion versus bolus
نویسندگان
چکیده
Background Myocardial extracellular volume fraction (Ve) measures from myocardial and blood pool T1 data quantify diffuse fibrosis (Flett, 2010) not detectable by conventional late gadolinium (Gd) enhancement, but require steady state equilibrium between plasma and interstitium. While a bolus with a lengthy infusion produces steady state for Ve measures, it is unclear whether a Gd contrast bolus alone (e.g., Broberg, 2010) is sufficient. Given the relatively slow clearance of Gd, we hypothesized that a simple bolus accurately measures Ve, thus facilitating integration of Ve measurement into CMR workflow routines.
منابع مشابه
Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
BACKGROUND Myocardial extravascular extracellular volume fraction (Ve) measures quantify diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement (LGE). Ve measurement requires steady state equilibrium between plasma and interstitial Gd contrast. While a constant infusion produces steady state, it is unclear whether a simple bolus can do the same. Given the relat...
متن کاملCardiac T1 mapping in congenital heart disease: bolus versus infusion protocol for measurement of myocardial extracellular volume
Background Measurement of myocardial extracellular volume fraction (ECV) with T1 mapping cardiac magnetic resonance (CMR) before and after the application of a gadolinium-based extracellular contrast agent enables the assessment of diffuse myocardial fibrosis. The equilibrium between blood and myocardium contrast concentration required for ECV measurements can be achieved with a primed contrast...
متن کاملT1 mapping for myocardial extracellular volume measurement by cardiovascular magnetic resonance: bolus only vs primed infusion technique
Background Myocardial ECV can be measured using T1 mapping before and after contrast if the contrast agent distribution between blood:myocardial is at equilibrium. Equilibrium distribution can be achieved with a primed contrast infusion (EQ-CMR), or may be approximated by the dynamic equilibration achieved by delayed post bolus measurement. This bolus only approach is highly attractive but curr...
متن کاملT1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique.
OBJECTIVES The aim of this study was to determine the accuracy of the contrast "bolus only" T1 mapping cardiac magnetic resonance (CMR) technique for measuring myocardial extracellular volume fraction (ECV). BACKGROUND Myocardial ECV can be measured with T1 mapping before and after contrast agent if the contrast agent distribution between blood/myocardium is at equilibrium. Equilibrium distri...
متن کاملMyocardial T1 and extracellular volume fraction mapping at 3 tesla
BACKGROUND To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV). METHODS Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 1...
متن کامل