Effects of radioiodine administration on serum concentrations of matrix metalloproteinases, adiponectin and thrombospondin
نویسندگان
چکیده
Introduction In order to assess long-term safety of radioactive iodine administration in treatment of thyrotoxicosis, we assessed concentrations of selected markers of risk cardiovascular disease, i.e. matrix metalloproteinase 2 (MMP-2), its main inhibitor TIMP-2, matrix metalloproteinase 9 (MMP-9), its main inhibitor TIMP-1, as well concentrations of anti-inflammatory adiponectin and pro-inflammatory thrombospondin.
منابع مشابه
Effects of radioiodine administration on serum concentrations of matrix metalloproteinases, adiponectin and thrombospondin-1
BACKGROUND In order to assess safety of radioactive iodine administration in the treatment of thyrotoxicosis, we measured concentrations of matrix metalloproteinase-2 (MMP-2), its main inhibitor - TIMP-2 (tissue inhibitor of MMP-2), matrix metalloproteinase-9 (MMP-9), its main inhibitor - TIMP-1, adiponectin, as well as pro-inflammatory and procancerogenic thrombospondin-1 (TSP-1). DESIGN AND...
متن کاملIn contrast to matrix metalloproteinases, serum adiponectin concentrations increase after radioiodine treatment of thyrotoxicosis
UNLABELLED BACKGROUND Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), remodel extracellular matrix under physiological and pathological conditions and are implicated in pathogenesis of cardiovascular diseases, cancer and in chronic inflammation. We have endeavoured to assess whether concentrations of MMPs, TIMPs, and anti-inflammatory adiponectin are altered ...
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