The Neural Correlates of Optimistic and Depressive Tendencies of Self-Evaluations and Resting-State Default Mode Network

Unrealistic optimism is common among people making self-evaluations while reduced optimism has been linked to increased depressive symptoms. Given the importance of optimism for adaptive functioning, surprisingly little is known about resting brain states underlying optimistic and depressive tendencies. In the current study, two resting-state indices were used to examine neural correlates of the default mode network (DMN) associated with optimistic and depressive self-evaluation tendencies in a non-clinical young adult sample (N = 49). The analysis was constrained due to the self-referential nature of the DMN. Across different indices, bilateral superior frontal gyri of the dorsolateral prefrontal cortex (DLPFC) and bilateral superior medial frontal gyri of the dorsal medial prefrontal cortex (DMPFC) played a key role in maintaining spontaneous optimistic self-evaluative tendencies. Conversely, decreased activity in the DLPFC and bilateral medial orbitofrontal cortices (OFC) were related to accentuated depressive symptoms. Together, results highlight the pivotal roles of the DLPFC and DMPFC in mediating valences of self-referential content.