Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro.

نویسندگان

  • Antonella Torosantucci
  • Paola Chiani
  • Flavia De Bernardis
  • Antonio Cassone
  • Jose Antonio Calera
  • Richard Calderone
چکیده

We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null strain. This observation may partially explain the reduced virulence in a hematogenously disseminated murine model of candidiasis.

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عنوان ژورنال:
  • Infection and immunity

دوره 70 2  شماره 

صفحات  -

تاریخ انتشار 2002