Peptides’ role in autism with emphasis on exorphins
نویسندگان
چکیده
PROBLEM The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid-acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. RESULTS We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. CONCLUSION Exorphins are found in urine of autistic children and may account for their symptoms.
منابع مشابه
Can the pathophysiology of autism be explained by the nature of the discovered urine peptides?
Opioid peptides derived from food proteins (exorphins) have been found in urine of autistic patients. Based on the work of several groups, we try to show that exorphins and serotonin uptake stimulating factors may explain many of the signs and symptoms seen in autistic disorders. The individual symptoms ought to be explainable by the properties and behavioural effects of the found peptides. The...
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