Title: Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in an inflammatory arthritis mouse model. Short title: C-type natriuretic peptide protects cartilage during arthritis
نویسندگان
چکیده
cartilage integrity in an inflammatory arthritis mouse model. Short title: C-type natriuretic peptide protects cartilage during arthritis Hülya Bükülmez, MD., Fozia Khan, PhD., Cynthia F. Bartels, MS., Shunichi Murakami MD., PhD., Adriana Ortiz-Lopez, PhD., Abdus Sattar, PhD., Tariq M. Haqqi, PhD., Matthew L. Warman, MD. Corresponding author: Hülya Bükülmez, MD, Skeletal Research Center, Department of Biology, College of Arts and Sciences and Pediatric Rheumatology, and Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, Address: Department of Pediatrics, Pediatric Rheumatology, 2500 MetroHealth Drive, Cleveland, OH, 44106. Tel: 216-778-4284, Fax: 216-778-2857, e-mail: [email protected], Supported by grants from the Arthritis National Research Foundation and from NIH/NIAMS K08 AR053943-01, and from NIH/NCCAM R01 AT 0036227; R01 AT 005520; and R21 AT 004026. Authors do not have any financial supports from commercial sources, thus no conflicts of interest. Full Length Arthritis & Rheumatism DOI 10.1002/art.38199
منابع مشابه
Protective Effects of C-Type Natriuretic Peptide on Linear Growth and Articular Cartilage Integrity in a Mouse Model of Inflammatory Arthritis
OBJECTIVE The C-type natriuretic peptide (CNP) signaling pathway is a major contributor to postnatal skeletal growth in humans. This study was undertaken to investigate whether CNP signaling could prevent growth delay and cartilage damage in an animal model of inflammatory arthritis. METHODS We generated transgenic mice that overexpress CNP (B6.SJL-Col2a1-NPPC) in chondrocytes. We introduced ...
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