Chloramphenicol (chloromycetin), an Antibiotic. Pharmacological and Pathological Studies in Animals.
نویسندگان
چکیده
It is a neutral white crystalline substance with a bitter taste and is stable in neutral and acid solutions. The drug is moderately soluble in water (0.25 per cent at room temperature, 0.65 per cent at 700 C and up to 15 per cent in propylene glycol, 5 per cent in 50 per cent acetamide), and is insoluble in vegetable oils. Solubility in urine or serum is about the same as in water. Solutions are stable on heating.
منابع مشابه
BIOCHEMICAL STUDIES ON CHLORAMPHENICOL (CHLOROMYCETIN*) III. ISOLATION AND IDENTIFICATION OF METABOLIC PRODUCTS IN URINEt
When chloramphenicol is administered by mouth to normal human subjects, only 5 to 10 per cent of the administered dose is excreted unchanged in the urine, as determined by microbiological assay methods (3, 4). However, with calorimetric methods for aromatic nitro compounds (5), from 75 to 90 per cent of the administered dose is accounted for in 24 hour urinary excretion in man (3). The major po...
متن کاملبررسی آزاد شدن آندوتوکسین از سالمونلا تیفی توسط آنتی بیوتیک ها به روش لیمولوس آمیبوسایت لیسایت کروموژنیک
It seems, rapid destruction of gram negative bacteria by antibiotics contribute to the clinical deterioration of some patients with lethal endotoxemia. In this research we evaluated LPS (lipopolysaccharide) release during antibiotic killing of salmonella typhi (Ty2-5536). The organism was incubated in the presence of Chloramphenicol, Ampicillin and Co-trimoxazole at concentrations that killed >...
متن کاملA study to compare the use of fusidic acid viscous eye drops and chloramphenicol eye ointment in an accident and emergency department.
A total of 300 patients attending an Accident and Emergency department with ophthalmic complaints needing topical antibiotic treatment were treated with fucithalmic or chloramphenicol (chloromycetin). Their compliance and the incidence of side effects were assessed. There was a 70.3% response rate to the questionnaire. Of the patients 51.3% using fucithalmic completed the 5 day course compared ...
متن کاملEnrichment of cadmium-mediated antibiotic-resistant bacteria in a Douglas-fir (Pseudotsuga menziesii) litter microcosm.
A set of Douglas-fir needle litter microcosms was amended with cadmium, acid, a combination of both, or neither. After 2 weeks of incubation, bacterial colony counts were made of litter homogenates inoculated onto agar media containing an antibiotic (streptomycin, chloromycetin, ampicillin, or gentamicin), cadmium, both, or neither. In all microcosms bacterial abundance was similar but the qual...
متن کاملEffect of chloramphenicol on the isolation of S. typhi from the blood stream.
The usually excellent clinical response to chloramphenicol in typhoid fever has been accompanied in practically all the recorded series by a rapid disappearance of organisms from the blood stream. Cook and Marmion (1949) state: " The action of 'chloromycetin' appears to be to arrest the disease at whatever stage it has reached and to sterilize the blood at the same time." Marmion (1952) in a se...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 28 5 Pt 1 شماره
صفحات -
تاریخ انتشار 1949