Anti-Tubercular Compounds from SpondiasMombin
نویسندگان
چکیده
Spondiasmombin is a widely cultivated edible plant used in folkloric medicine for the treatment of severe cough and other respiratory disorders. This study evaluated the anti tubercular property of the stem of S. mombin against Mycobacterium tuberculosis (H37Rv and EJA-2011) using agar proportion assay on Lowenstein-Jensen medium. Four new compounds were isolated from the stem of Spondiasmombin and they were identified as mombinrin (1), mombincone (2), mombinoate (3) and mombinol (4) respectively. Compound 1 is a coumarin, 2-4 are flavonoids. At 40 μg/mL concentration, the four compounds exhibited significant inhibitions (p < 0.05) against M. tuberculosis. At a lower dose of 25 μg/mL,compounds 1 and 3 exhibited significant antimycobacterial inhibitions (96.0% and 97.6% respectively; p < 0.05) while compounds 2 and 4 showed moderate inhibitions (85.0% and 88.0% respectively). The findings show that Spondiasmombin accumulates antimycobacterial compounds that may serve as an important potential source for antitubercular agents.
منابع مشابه
Synthesis and Evaluation of New Fluorinated Anti-Tubercular Compounds
Treatment of tuberculosis (TB) and the discovery of effective new anti tubercular drugs is one of the most urgent priorities in health organizations all around the world. In the present study, fluorinated analogs of some of the most important anti-TB agents such as p-aminosalicylic acid (PAS), thiacetazone and pyrazinamide were synthesized and tested against TB. The fluorinated analog of thiace...
متن کاملSynthesis and Evaluation of New Fluorinated Anti-Tubercular Compounds
Treatment of tuberculosis (TB) and the discovery of effective new anti tubercular drugs is one of the most urgent priorities in health organizations all around the world. In the present study, fluorinated analogs of some of the most important anti-TB agents such as p-aminosalicylic acid (PAS), thiacetazone and pyrazinamide were synthesized and tested against TB. The fluorinated analog of thiace...
متن کاملSynthesis and anti-tubercular activity of 6-Substtitutedaryl-4-Arylidene-4,5-dihydropyridazin-3(2H)-one derivatives against Mycobacterium tuberculosis
Pyridazine plays a significant role in pharmaceuticals particularly in the field of medicinal chemistry. Several 4-substituted-benzylidene-6-substituted-phenyl-dihydro-pyridazin-3(2H)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. In the first step, 6-aryl-tetrahydro-pyridazin-3-ones (2) were prepar...
متن کاملDesign and synthesis of quinazolinone derivatives as a novel antitubercular agents
Quinazolinone is a compound made up of two fused six member simple aromatic rings-benezene and pyrimidine ring and have been reported to posses versatile type of biological activities such as anticancer, anticonvulsant, antiinflammatory, antihelminthic, antimicrobial activities. A series of novel substituted[1,2,4]triazolo[1,5c]quinazolinone derivatives (K11-19) were synthesized by mannich reac...
متن کاملSynthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides
We demonstrated that the 3-substituted benzothiophene-1,1-dioxide class of compounds are effective inhibitors of Mycobacterium tuberculosis growth under aerobic conditions. We examined substitution at the C-3 position of the benzothiophene-1,1-dioxide series systematically to delineate structure-activity relationships influencing potency and cytotoxicity. Compounds were tested for inhibitory ac...
متن کامل