Co-Inhibitory Suppression of T Cell Activation by CD40 Protects from Obesity and Adipose Tissue Inflammation in Mice
نویسندگان
چکیده
Dennis Wolf, MD; Felix Jehle, MD; Nathaly Anto Michel, MSc; Eva Nora Bukosza, MD; Jennifer Rivera, PhD; Yung Chi Chen, PhD; Natalie Hoppe, BSc; Bianca Dufner, BSc; Alexandra Ortiz Rodriguez, MSc; Christian Colberg, MSc; Leandro Nieto, BSc; Benjamin Rupprecht, BSc; Ansgar Wiedemann, MSc; Lisa Schulte, BSc; Alexander Peikert, BSc; Nicole Bassler, BSc; Andrey Lozhkin, MSc; Sonja Patricia Hergeth, PhD; Peter Stachon, MD; Ingo Hilgendorf, MD; Florian Willecke, MD; Constantin von zur Mühlen, MD; Dominik von Elverfeldt, PhD; Christoph J. Binder, MD, PhD; Peter Aichele, MD; Nerea Varo, MD; Mark A. Febbraio, PhD; Peter Libby, MD; Christoph Bode, MD; Karlheinz Peter, MD, PhD; Andreas Zirlik, MD
منابع مشابه
Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice.
BACKGROUND Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and inflammation during atherosclerosis. Here, we tested the hypothesis that CD40 directly modulates traits of the metabolic syndrome in diet-induced obesity in mice. METHODS AND RESULTS To induce the metabolic syndrome, wild-type or CD40(-/-) mice consumed a high-fat diet for 20 weeks. Unexpectedly, ...
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The pathophysiology of obesity and type 2 diabetes in rodents and humans is characterized by low-grade inflammation in adipose tissue and liver. The CD40 receptor and its ligand CD40L initiate immune cell signaling promoting inflammation, but conflicting data on CD40L-null mice confound its role in obesity-associated insulin resistance. Here, we demonstrate that CD40 receptor-deficient mice on ...
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