SAP Minutes No. 2010-06 A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: SHEDS-Multimedia version 4, Peer Consult on PBPK Modeling, and a SHEDS-PBPK Permethrin Study

SAP Minutes No. 2011-03 A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Chlorpyrifos Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling Linked to Cumulative and Aggregate Risk Evaluation System

SAP Minutes No. 2004-06 A Set of Scientific Issues Being Considered by the Environmental Protection Agency Regarding: FUMIGANT BYSTANDER EXPOSURE MODEL REVIEW: PROBABILISTIC EXPOSURE AND RISK MODEL FOR FUMIGANTS (PERFUM) USING IODOMETHANE AS A CASE STUDY

NOTICE These meeting minutes have been written as part of the activities of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), Scientific Advisory Panel (SAP). The meeting minutes represent the views and recommendations of the FIFRA SAP, not the United States Environmental Protection Agency (Agency). The content of the meeting minutes does not represent information approved or dis...

Pesticide regulations: exposure-dose modeling from FIFRA to FQPA.

The federal laws and regulations governing the registration and use of pesticides in the United States under the Federal Insecticide, Fungicide, and Rodenticide Act are published in the Federal Register, while state laws such as California are published in the California Food and Agricultural Code, Divisions 6, 7, and 13. Up until the passage of the Food Quality Protection Act (FQPA of 1996), f...

Scientific Issues Being Considered by the Environmental Protection Agency Regarding: Session I - Test Guidelines for Chronic Inhalation Toxicity and Carcinogenicity of Fibrous Particles

NOTICE This report has been written as part of the activities of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), Scientific Advisory Panel (SAP). This report has not been reviewed for approval by the United States Environmental Protection Agency (Agency) and, hence, the contents of this report do not necessarily represent the views and policies of the Agency, nor of other agenc...

Physiologically based pharmacokinetic model use in risk assessment--Why being published is not enough.

A panel of experts in physiologically based pharmacokinetic (PBPK) modeling and relevant quantitative methods was convened to describe and discuss model evaluation criteria, issues, and choices that arise in model application and computational tools for improving model quality for use in human health risk assessments (HHRAs). Although publication of a PBPK model in a peer-reviewed journal is a ...