CALL FOR PAPERS Sex and Gender Differences in Renal Physiology Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation
نویسندگان
چکیده
Lorena Rojas-Vega, Luis A. Reyes-Castro, Victoria Ramírez, Rocío Bautista-Pérez, Chloe Rafael, María Castañeda-Bueno, Patricia Meade, Paola de los Heros, Isidora Arroyo-Garza, Valérie Bernard, Nadine Binart, Norma A. Bobadilla, Juliette Hadchouel, Elena Zambrano, and Gerardo Gamba Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico; Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico; INSERM UMR970, Paris Cardiovascular Research Center, Paris, France; University ParisDescartes, Sorbonne Paris Cité, Faculty of Medicine, Paris, France; Escuela de Medicina, Universidad Panamericana, Mexico City, Mexico; INSERM U693, Le Kremlin-Bicêtre Université Paris-Sud, Faculté de Médecine Paris-Sud, UMR-S693, Le Kremlin-Bicêtre, France; and Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Le Kremlin Bicêtre, France
منابع مشابه
Ovarian hormones and prolactin increase renal NaCl cotransporter phosphorylation.
Unique situations in female physiology require volume retention. Accordingly, a dimorphic regulation of the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) has been reported, with a higher activity in females than in males. However, little is known about the hormones and mechanisms involved. Here, we present evidence that estrogens, progesterone, and prolactin stimulate NCC expression and ph...
متن کاملMini-review: regulation of the renal NaCl cotransporter by hormones.
The renal thiazide-sensitive NaCl cotransporter, NCC, is the major pathway for salt reabsorption in the distal convoluted tubule. The activity of this cotransporter is critical for regulation of several physiological variables such as blood pressure, serum potassium, acid base metabolism, and urinary calcium excretion. Therefore, it is not surprising that numerous hormone-signaling pathways reg...
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The activity of the renal thiazide-sensitive NaCl cotransporter (NCC) in the distal convoluted tubule plays a key role in defining arterial blood pressure levels. Increased or decreased activity of the NCC is associated with arterial hypertension or hypotension, respectively. Thus it is of major interest to understand the activity of NCC using in vivo models. Phosphorylation of certain residues...
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Sharma N, Li L, Ecelbarger CM. Sex differences in renal and metabolic responses to a high-fructose diet in mice. Am J Physiol Renal Physiol 308: F400–F410, 2015. First published December 23, 2014; doi:10.1152/ajprenal.00403.2014.—High fructose intake has been associated with increased incidences of renal disease and hypertension, among other pathologies. Most fructose is cleared by the portal s...
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The kidney plays an essential role in blood pressure regulation by controlling short-term and long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) reabsorbs 25-30% of the NaCl filtered by the glomeruli in a process mediated by the apical Na(+)-K(+)-2Cl(-) cotransporter NKCC2, which allows Na(+) and Cl(-) entry from the tubule lumen into TAL cells. In humans, mut...
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