Down-Regulated during Inflammation Mononuclear Blood Leukocytes and Strongly Neuropeptide Y Is Expressed by Rat
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Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis.
HYPOTHESIS Blood leukocytes play a major role in mediating local and systemic inflammation during acute pancreatitis. We hypothesize that peripheral blood mononuclear cells (PBMCs) in circulation exhibit unique changes in gene expression and could provide a "reporter" function that reflects the inflammatory response in the pancreas with acute pancreatitis. DESIGN To determine specific changes...
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