Thiazorifamycins. III. Biosynthesis of rifamycins P, Q and verde, novel metabolites from a mutant of Nocardia mediterranea.
نویسندگان
چکیده
The thiazorifamycins are derived from rifamycin S and cysteine; rifamycins P and Verde are formed by chemical reactions, while rifamycin Q synthesis involves obligatory enzymatic assistance. All antibiotics come from a common six-member precursor lacking C-1 of cysteine; the thiazin-2-one ring of rifamycin Verde retains both C-2 and C-3 of cysteine, while the thiazole ring of rifamycins P and Q retains only C-2, C-3 becoming exocyclic in the ring-contraction C-3 is present in rifamycin Q but not in P.
منابع مشابه
An Australian isolate of Nocardia mediterranea producing rifamycin SV.
Since its first announcement by P. Sensi et at. in 19591}, the rifamycin complex has been extensively studied by a number of workers2). The type culture Nocardia mediterranea (Margalith et Beretta) Thiemann et at. 1969*, then known as Streptomyces mediterranei^ was isolated from a soil sample collected in France. Sugawara et al.l) culturing an isolate (4107 A2) from a Japanese soil sample, repo...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 33 8 شماره
صفحات -
تاریخ انتشار 1980