Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens.
نویسندگان
چکیده
Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 41 12 شماره
صفحات -
تاریخ انتشار 1997