5'-Uridyl derivatives of N-glycosyl allophanic acid and biuret.
نویسندگان
چکیده
(2',3'-O-Isopropylidene-5'-uridyl) 4-(2,3,4,6-tetra-O-acetyl-beta-d-glycopyranosyl)allophanates were obtained in the reactions of 2',3'-O-isopropylidene-uridine and O-peracetylated beta-d-gluco-, galacto- and xylopyranosylamines, and OCNCOCl. 2,3,4,6-Tetra-O-acetyl-beta-d-glucopyranosyl isocyanate and N-(2',3'-O-isopropylidene-5'-uridyl)urea gave 1-(2,3,4,6-tetra-O-acetyl-beta-d-glucopyranosyl)-5-(2',3'-O-isopropylidene-5'-uridyl)biuret. Deprotection of the beta-d-gluco configured allophanate and biuret was carried out by standard methods.
منابع مشابه
Antinociceptive effect of some biuret derivatives on formalin test in mice.
PURPOSE The current study was designed to investigate the antinociceptive effects of several biuret derivatives with N, N`-diphenyl, N-phenyl-N`-alkylphenyl, N,N`-bis alkylphenyl, 2-methylquinoline-4-yl, benzo[d]thiazol-2-ylthio and (1-phenyl-1H-tetrazol-5-yl)thio substituents on the formalin-evoked pain in mice. METHODS Antinociceptive activity of the nine biurets derivatives were assessed a...
متن کاملGas-liquid Chromatography of Carbohydrate Derivatives: the Separation and Quantitative Determination of Synthetic and Naturally Occurring Glycosyl Derivatives of Amino Acids*
A gas-liquid chromatographic separation of the trimethylsilyl derivatives of several synthetic and naturally occurring glycosyl derivatives of amino acids is described. This technique may be used for the qualitative and quantitative determination of several compounds of biological interest including 3-O-j?-D-xylopyranosylr-serine, 3-O-a-L-arabinopyranosyl-L-serine, 5-0-/3-o-galactopyranosyloxy-...
متن کاملSynthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives.
5 Synthesis and biological evaluation of a series (N = 16) of cyclic and acyclic hydroxyurea derivatives, including benzotriazole-, isocyanuric acid- and biuret-containing compounds, are disclosed. 1-N-(benzyloxycarbamoyl)benzotriazole was used as a benzyloxyisocyanate donor, a useful intermediate in the preparation of substituted hydroxyurea. Antibacterial activities of synthesized hydroxyurea...
متن کاملCross-reactivity of amino acids and other compounds in the biuret reaction: interference with urinary peptide measurements.
BACKGROUND Biuret assays for total protein measurement are considered to react with all peptides longer than 2 residues. Some studies using biuret assays of urine suggest that small peptides generally are more abundant than proteins in urine, but it is not clear whether this is a problem of assay specificity. METHODS We analyzed the specificity and kinetics of a biuret reaction for solutions ...
متن کاملNovel glycosylation reactions using glycosyl thioimidates of N-acetylneuraminic acid as sialyl donors.
Novel sialyl donors 4 bearing a thioimidolyl moiety as the leaving group were successfully prepared from the corresponding arylthio derivatives 3 and a peracetylated chloro derivative of Neu5Ac 2 in the presence of N,N-di-isopropylethylamine with moderate yields. The reaction of 4 with various alcohols 5 was effectively activated by AgOTf as the promoter to give the corresponding O-sialosides 6...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Carbohydrate research
دوره 345 1 شماره
صفحات -
تاریخ انتشار 2010