PARV4: An Emerging Tetraparvovirus
نویسندگان
چکیده
1 Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom, 2 Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, United Kingdom, 3 Department of Paediatrics, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom, 4 The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom, 5 NIHR Biomedical Research Centre, John Radcliffe Hospital, Headington, Oxford, United Kingdom
منابع مشابه
Human parvovirus 4 ‘PARV4’ remains elusive despite a decade of study
Human parvovirus 4 ('PARV4') is a small DNA tetraparvovirus, first reported in 2005. In some populations, PARV4 infection is uncommon, and evidence of exposure is found only in individuals with risk factors for parenteral infection who are infected with other blood-borne viruses. In other settings, seroprevalence studies suggest an endemic, age-associated transmission pattern, independent of an...
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In a post hoc analysis of samples collected in 2009, we determined seroprevalence of parvovirus 4 (PARV4) among elderly Cameroonians. PARV4 seropositivity was associated with receipt of intravenous antimalarial drugs, intramuscular streptomycin, or an intramuscular contraceptive, but not hepatitis C virus seropositivity. Findings suggest parenteral acquisition of some PARV4 infections.
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In studying the epidemiology of parvovirus 4 (PARV4) in Taiwan, we detected DNA in plasma of 3 mothers and their newborns with hydrops. In 1 additional case, only the mother had PARV4 DNA. Our findings demonstrate that PARV4 can be transmitted through the placenta.
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samples in age groups highlighted a relative homogeneity throughout the corresponding cohort. Our study shows that PARV4 infection is readily detectable in French blood donors. Prevalence results using probe PARV4-O were comparable to those obtained in previous studies involving healthy persons originating from various countries (4–6). Conversely, the high prevalence obtained by using probe PAR...
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Human parvovirus 4 (PARV4) is an emerging human virus, and little is known about the molecular aspects of PARV4 apart from its incomplete genome sequence, which lacks information of the termini. We analyzed the gene expression profile of PARV4 using a nearly full-length HPV4 genome in a replication competent system in 293 cells. We found that PARV4 utilizes two promoters to transcribe non-struc...
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