Py-Im Polyamides Distinguish Double Helical DNA and RNA**
نویسندگان
چکیده
Groove specificity. Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. Here we demonstrate that polyamides do not similarly bind duplex RNA, and offer a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor groove binding ligands.
منابع مشابه
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