(OMMENT Quinacrine Pellets: An Examination
نویسندگان
چکیده
The demand for sterilization is increasing in many countries1 In fact, female sterilization is the most wide ly used contraceptive method, with over 138 million married women of reproductive age relying on its protection. In industrial&d countries, the average woman now achieves her desired family size within six years of marriage, and spends 50% of her reproductive life potentially fertile but not wanting any more children? In developing countries, with an expanding number of women in fertile age-groups and a backlog of unmet need for fertility control, an estimated 150 million new sterilizations-many of them female sterilizations--could be performed in many of these countries during the 199Os.j Female sterilization has been considerably simplified over the past few years, particularly with the introduction and widespread utilization of minilaparotomy, which can be performed as an outpatient procedure. Despite these advances, female sterilization is a surgical procedure;
منابع مشابه
Clinico-pathological study of fallopian tubes after transcervical insertion of quinacrine hydrochloride pellets.
This study lends support to others indicating the apparent safety and effectiveness of multiple transcervical insertions of quinacrine hydrochloride as pellets in 240 mg dosage to achieve permanent sterilization. In order to study the effects of the number of quinacrine pellet insertions and the site of placement of the pellets in the uterus of prehysterectomy volunteers, a scoring system of hi...
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To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed results are presented for one of the trials using 10-min pellets. Six of 10 wo...
متن کاملEfficacy of two insertions of 100-minute releasing quinacrine hydrochloride pellets for non-surgical female sterilization.
Extensive research has been undertaken to develop a simple method of non-surgical female sterilization. Zipper and associates identified quinacrine hydrochloride as a drug likely to produce tubal occlusion when placed into the uterus. Zipper's early work with a solution of quinacrine led to the development of quinacrine pellets, a delivery system that was designed to bring the quinacrine into p...
متن کاملEfficacy and safety of repeated transcervical quinacrine pellet insertions for female sterilization.
OBJECTIVE To investigate the rates of tubal occlusion, pregnancy, and side effects of repeated, monthly transcervical insertions of 252 mg quinacrine as pellets. DESIGN Clinical trial among 159 reproductive age women receiving two monthly transcervical insertions of 252 mg of quinacrine followed by hysterosalpingograms (HSGs) 1 month after last insertion and an additional monthly insertion am...
متن کاملTranscervical quinacrine sterilization: clinical experience.
OBJECTIVE To review the use of quinacrine pellets for non-surgical female sterilization. BACKGROUND The transcervical insertion of quinacrine pellets has been under study for over 15 years. It could potentially expand access to sterilization services, because it is relatively simple to administer, with the use of a modified IUD inserter, and is inexpensive. METHODS Published and unpublished...
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