PMTCT of HIV-1 in Burkina Faso: evaluation of residual vertical transmission by PCR, molecular characterization of subtypes and determination of antiretroviral drugs resistance
نویسندگان
چکیده
Results In this study, 12.26% (394/3215) of the pregnant women were diagnosed HIV-positive, 0.52% (2/388) overall residual rate of transmission was identified with rates of 1.75% (2/114) among mothers under prophylaxis and 0.00% (0/274) for those under HAART. Genetic mutations have also been isolated that induce resistance to ARVs like M184V, Y115F, K103N, Y181C, v179E, G190A, etc. And there were subtypes and circulating recombinant forms (CRF) of HIV-1 such as: CRF06_CPX (58.8%), CRF02_AG (35.3%) and subtype G (5.9%). Conclusion Antiretroviral drugs reduce the residual rate of HIV vertical transmission. However, they cause mutations that induce resistance of HIV to antiretroviral therapy. Resistance to ARV therefore requires a permanent dialogue between clinicians, prescribers, pharmacists, and the creation of a network of monitoring and surveillance of drug resistance in Burkina Faso.
منابع مشابه
Prevention of mother-to-child HIV-1 transmission in Burkina Faso: evaluation of vertical transmission by PCR, molecular characterization of subtypes and determination of antiretroviral drugs resistance
BACKGROUND Vertical human immunodeficiency virus (HIV) transmission is a public health problem in Burkina Faso. The main objective of this study on the prevention of mother-to-child HIV-1 transmission was to determine the residual risk of HIV transmission in infants born to mothers receiving highly active antiretroviral therapy (HAART). Moreover, we detect HIV antiretroviral (ARV) drug resistan...
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