TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and Mei- P26, leads to tumorous phenotypes in neural and germline stem cell
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چکیده
TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and MeiP26, leads to tumorous phenotypes in neural and germline stem cell lineages, respectively. These phenotypes are caused, at least in part, by the expression of dMyc. Here, the authors show that in the wing epithelium, dMyc overexpression or Brat depletion do not cause tissue overgrowth because Mei-P26 is up-regulated. Thus, Brat and Mei-P26 act as context-dependent tumor suppressors.
منابع مشابه
Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila.
TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation, and differentiation during development. Drosophila Brat and Mei-P26 TRIM-NHL proteins serve as tumor suppressors in stem cell lineages and have been proposed to exert this action, in part, via the repression of the protooncogene dMyc. Here we analyze the role of Brat, Mei-P26, and dMyc in regulat...
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TRIM-NHL proteins are conserved among metazoans and control cell fate decisions in various stem cell linages. The Drosophila TRIM-NHL protein Brain tumor (Brat) directs differentiation of neuronal stem cells by suppressing self-renewal factors. Brat is an RNA-binding protein and functions as a translational repressor. However, it is unknown which RNAs Brat regulates and how RNA-binding specific...
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