Citicoline preclinical and clinical update 2009-2010.
نویسندگان
چکیده
Citicoline is a neuroprotectant and neurorestorative drug that is used in the treatment of acute ischemic stroke in some countries. The research with this compound continues. In this review, we focus on the latest publications or communications or both and on the major ongoing experimental and clinical projects involving citicoline in stroke recovery.
منابع مشابه
Citicoline: pharmacological and clinical review, 2016 update.
This review is based on the previous one published in 2010 -Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62-, incorporating 183 new references, having all the information available to facilitate the access to the information in one document. This review is focused on the main indications of the drug, as acute stroke and its sequelae...
متن کاملCiticoline: pharmacological and clinical review, 2010 update
Introduction S1 Pharmacological actions S2 Traumatic lesions and experimental cerebral oedema S2 Cerebral hypoxia and ischaemia S5 Synaptic transmission and neurotransmitter levels S13 Learning performance, memory and brain ageing S17 Experimental withdrawal syndrome and intoxications S19 Toxicity S20 Acute toxicity S20 Subacute toxicity S20 Chronic toxicity S20 Teratogenicity S20 Pharmacokinet...
متن کاملNeuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issues
Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-5'-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine. Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately ...
متن کاملCiticoline: update on a promising and widely available agent for neuroprotection and neurorepair.
Choline precursors promote repair and growth of cell membranes and hold promise in a variety of neurologic diseases, including ischemic and hemorrhagic stroke. Citicoline, the most well-studied choline agent precursor, is widely prescribed throughout the world and recently became available in the United States as a dietary supplement. In experimental stroke models, citicoline conferred acute ne...
متن کاملERRATUM: Citicoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
[This corrects the article on p. 33 in vol. 5, PMID: 19513332.].
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Stroke
دوره 42 1 Suppl شماره
صفحات -
تاریخ انتشار 2011