Ototoxicity of Acetic Acid: A Short Review
نویسنده
چکیده
Various drugs, in the form of ear drops or topical irrigation, are used to treat chronic discharging ears. Recently, Burow’s solution has gained popularity for its excellent antibacterial and antifungal activity. A specifically interesting attribute of this solution to clinicians is its efficacy in treating MRSA, i.e., Methicillin-Resistant Staphylococcus aureus as well as various other antibiotic-resistant bacteria and fungi. 13% aluminum acetate is the main component of this solution. The original Burow’s solution 3.5 pH and, when it was applied in a guinea pig’s middle ear cavity for 30 min or longer, it induced a curtailment in the compound action potential (CAP). But, a twofold diluted Burow’s solution having higher pH of 4.4 led to no curtatilment in the CAP threshold [3].
منابع مشابه
Ototoxicity of acetic acid on the guinea pig cochlea
BACKGROUND To evaluate the ototoxicity of acetic acid solutions. METHODS Compound action potentials (CAPs) of the eighth nerve were measured in guinea pigs before and after the application of acetic acid in the middle ear cavity. The pH values of the acetic acid solutions were pH 3.0, 4.0, and 5.0, and the application times were 30 min, 24 h, and 1 week. RESULTS Acetic acid solution (pH 3.0...
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