Microwave Assisted Facile Synthesis and Biological Evaluation of Novel 2-Indolyl -1, 5-Benzothiazepines

نویسندگان

  • Anna P. G. Nikalje
  • Mangesh S. Ghodke
  • Firoz A. K. Khan
  • Jaiprakash N. Sangshetti
چکیده

The research work reports facile, eco-friendly microwaveassisted solvent free synthesis of coupled heterocyclic system 2-(1Hindol-3-yl)-4-substitued-2, 3-dihydrobenzo [1, 5] thiazepine derivatives obtained by cyclo condensation of 1-substituted-3(1Hindolyl)-2-propen-1-ones with 2-amino thiophenol in presence of eco-friendly catalyst zirconium(IV) oxy chloride, in solvent-free conditions. The reaction was completed in 3-6 minutes and gives better yields than the conventional synthesis which requires 6-8 hrs.

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تاریخ انتشار 2016