Transcranial electrical stimulation over visual cortex evokes phosphenes with a retinal origin.
نویسندگان
چکیده
Transcranial electrical stimulation (tES) is a promising therapeutic tool for a range of neurological diseases. Understanding how the small currents used in tES spread across the scalp and penetrate the brain will be important for the rational design of tES therapies. Alternating currents applied transcranially above visual cortex induce the perception of flashes of light (phosphenes). This makes the visual system a useful model to study tES. One hypothesis is that tES generates phosphenes by direct stimulation of the cortex underneath the transcranial electrode. Here, we provide evidence for the alternative hypothesis that phosphenes are generated in the retina by current spread from the occipital electrode. Building on the existing literature, we first confirm that phosphenes are induced at lower currents when electrodes are placed farther away from visual cortex and closer to the eye. Second, we explain the temporal frequency tuning of phosphenes based on the well-known response properties of primate retinal ganglion cells. Third, we show that there is no difference in the time it takes to evoke phosphenes in the retina or by stimulation above visual cortex. Together, these findings suggest that phosphenes induced by tES over visual cortex originate in the retina. From this, we infer that tES currents spread well beyond the area of stimulation and are unlikely to lead to focal neural activation. Novel stimulation protocols that optimize current distributions are needed to overcome these limitations of tES.
منابع مشابه
Bart Krekelberg evokes phosphenes with a retinal origin Transcranial electrical stimulation over visual cortex
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Transcranial electrical stimulation over visual cortex evokes 2 phosphenes with a retinal origin 3
36 37 Transcranial electrical stimulation (tES) is a promising therapeutic tool for a range of 38 neurological diseases. Understanding how the small currents used in tES spread across the scalp 39 and penetrate the brain will be important for the rational design of tES therapies. 40 41 Alternating currents applied transcranially above visual cortex induce the perception of flashes 42 of light (...
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Number: 949 Submitted By: Kohitij Kar Last Modified: December 1 2010 Retinal And Cortical Effects Of Transcranial Electric Stimulation Kohitij Kar, Bart Krekelberg Center for Molecular and Behavioral Neuroscience, Rutgers University Transcranial electric current stimulation (tES) of the human brain is assumed to affect cortical excitability by invoking subthreshold modulation of neuronal activi...
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Stimulation of the human visual cortex produces a transient perception of light, known as a phosphene. Phosphenes are induced by invasive electrical stimulation of the occipital cortex, but also by non-invasive Transcranial Magnetic Stimulation (TMS)(1) of the same cortical regions. The intensity at which a phosphene is induced (phosphene threshold) is a well established measure of visual corti...
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ورودعنوان ژورنال:
- Journal of neurophysiology
دوره 108 8 شماره
صفحات -
تاریخ انتشار 2012