Non invasive palliation for advanced pancreatic cancer using high intensity focused ultrasound
نویسندگان
چکیده
Background A majority of patients (85-90%) diagnosed with pancreatic cancer has advanced disease at the time of diagnosis with a dismal prognosis. Pain is a common symptom in patients (60-90%) with advanced disease. Pain is neuropathic and inflammatory, resulting from both tumour expansion and tumour invasion of the celiac and mesenteric plexus. Opioids have side effects and may not be sufficient while celiac plexus neurolysis is an invasive procedure, despite the questionable results reported. Currently, HIFU (high intensity focused ultrasound) an emerging procedure completely no invasive, has been gaining wide acceptance not only for treating neoplasm but for symptom’s relief also.
منابع مشابه
A meta-analysis of palliative treatment of pancreatic cancer with high intensity focused ultrasound
BACKGROUND Pancreatic adenocarcinoma is currently the fourth-leading cause of cancer-related death. Up to 60-90% of patients with advanced disease suffer cancer-related pain, severely impacting their quality of life. Current management involves primarily pharmacotherapy with opioid narcotics and celiac plexus neurolysis; unfortunately, both approaches offer transient relief and cause undesired ...
متن کاملEarly clinical experience using high intensity focused ultrasound for palliation of inoperable pancreatic cancer.
OBJECTIVE To evaluate the safety and efficacy of high intensity focused ultrasound for palliation of inoperable pancreatic cancer in humans. PATIENTS Eighty-nine patients with advanced pancreatic cancer were treated with high intensity focused ultrasound. There were 4 patients with stage II, 39 patients with stage III, and 46 patients with stage IV disease. The location of the tumors was as f...
متن کاملAnalgesic effect of high intensity focused ultrasound therapy for unresectable pancreatic cancer.
OBJECTIVE To evaluate the pain-alleviating action, feasibility and efficacy of high intensity focused ultrasound (HIFU) for palliation of inoperable pancreatic cancer in humans. METHODS Forty patients with advanced pancreatic cancer were treated with HIFU. There were 13 patients with stage III, and 27 patients with stage IV disease. The locations of the tumours were as follows: head of pancre...
متن کاملHigh-intensity focused ultrasound provides palliation for liver metastasis causing gastric outlet obstruction: case report
BACKGROUND Surgery is the standard of care in several oncologic diseases. However, when non-surgical candidates are not suitable for radical treatment, palliation must be achieved at least. High-intensity focused ultrasound uses ultrasound power that can be sharply focused for highly localised application, as it is a completely non-invasive procedure. Its non-invasiveness appears to be of param...
متن کاملHigh intensity focused ultrasound treatment for patients with local advanced pancreatic cancer.
BACKGROUND/AIMS To evaluate the safety and efficacy of high intensity focused ultrasound (HIFU) therapy in patients with local advanced pancreatic cancer. METHODOLOGY 39 patients with local advanced pancreatic cancer were treated with HIFU, including 26 male and 13 female patients. The locations of the tumours were as follows: head of pancreas in 7 patients, body and/or tail of pancreas in 32...
متن کامل