Notch and Tgfβ Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation
نویسندگان
چکیده
Yuefeng Tang, Sumithra Urs, Joshua Boucher, Tyler Bernaiche, Deepak Venkatesh, Douglas B. Spicer, Calvin P. H. Vary, and Lucy Liaw* Center for Molecular Medicine Maine Medical Center Research Institute Scarborough, ME, 04074, USA Running head: Notch regulates Smad-mediated transcription Address correspondence to: Lucy Liaw, Ph.D., Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, Tel 207-396-8142, Fax 207-396-8179, Email [email protected]
منابع مشابه
MicroRNA miR145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells.
RATIONALE MicroRNA miR145 has been implicated in vascular smooth muscle cell differentiation, but its mechanisms of action and downstream targets have not been fully defined. OBJECTIVE Here, we sought to explore and define the mechanisms of miR145 function in smooth muscle cells. METHODS AND RESULTS Using a combination of cell culture assays and in vivo mouse models to modulate miR145, we c...
متن کاملMolecular Pathways of Notch Signaling in Vascular Smooth Muscle Cells
Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and responds to Notch ligands as a regulatory mechanism of differentiation, recruitment to growing vessels, and maturation. The goal of this review...
متن کاملNotch and vascular smooth muscle cell phenotype.
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch gene regulatory network is often recapitulated in the context of phenotypic modulation of vascular smooth muscle cells (VSMC), vascular remodeling, and repair in adult vascular disease following injury. Not...
متن کاملReactive Oxygen Species in Vascular Formation and Development
Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduction pathways by reversible oxidation of certain signaling components and are ...
متن کاملNotch and Transforming Growth Factor- (TGF ) Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation*
Notch and transforming growth factor(TGF ) play pivotal roles during vascular development and the pathogenesis of vascular disease. The interaction of these two pathways is not fully understood. The present study utilized primary human smooth muscle cells (SMC) to examine molecular cross-talk between TGF 1 and Notch signaling on contractile gene expression. Activation of Notch signaling using N...
متن کامل