Stereoselective synthesis of activated 2-arylazetidines via imino-aldol reaction.
نویسندگان
چکیده
A simple and efficient synthetic route to substituted N-sulfinyl and N-sulfonyl azetidines is described involving imino-aldol reaction of ester enolates with racemic and non-racemic aldimines for obtaining β-amino esters as a key step. These β-amino esters on subsequent reduction followed by TsCl/KOH mediated cyclization produced the corresponding racemic and non-racemic azetidines with high yield and stereoselectivity.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 34 شماره
صفحات -
تاریخ انتشار 2015