Bioinspired Total Synthesis of Bussealin E.
نویسندگان
چکیده
The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative underwent an oxidative phenolic coupling to forge the tetracyclic ring system. The synthesis of the diphenylpropane featured a key sp2-sp3 Hiyama coupling between a vinyldisiloxane and a benzylic bromide.
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ورودعنوان ژورنال:
- Organic letters
دوره 20 6 شماره
صفحات -
تاریخ انتشار 2018